E4 interaction with a High Carb Diet
Combination of apolipoprotein E4 and high
carbohydrate diet reduces hippocampal BDNF and arc levels and impairs
memory in young mice.
http://www.ncbi.nlm.nih.gov/pubmed/22836186
We've
seen plenty of studies with human subjects suggesting that a high carb
diet (HCD) leads to cognitive impairment, but this is the first (to my
knowledge) that actually studied the effect of a HCD on e4s as compared
to e3s...albeit on our mousie friends
"Our
results indicate that HCD compromises memory processes in apoE4 mice.
ApoE4 mice on HCD showed decreased activity-regulated
cytoskeletal-associated protein (Arc) and brain derived neurotrophic
factor (BDNF) levels, as well as decreased BDNF signaling in the
hippocampus. In contrast, apoE3 mice were resistant to the deleterious
effects of HCD on both behavior and memory-related proteins. Our results
support the hypothesis that already in mid-life, genetic, and
environmental risk factors act together on the mechanisms behind
cognitive impairment."
carbohydrate diet reduces hippocampal BDNF and arc levels and impairs
memory in young mice.
http://www.ncbi.nlm.nih.gov/pubmed/22836186
We've
seen plenty of studies with human subjects suggesting that a high carb
diet (HCD) leads to cognitive impairment, but this is the first (to my
knowledge) that actually studied the effect of a HCD on e4s as compared
to e3s...albeit on our mousie friends
"Our
results indicate that HCD compromises memory processes in apoE4 mice.
ApoE4 mice on HCD showed decreased activity-regulated
cytoskeletal-associated protein (Arc) and brain derived neurotrophic
factor (BDNF) levels, as well as decreased BDNF signaling in the
hippocampus. In contrast, apoE3 mice were resistant to the deleterious
effects of HCD on both behavior and memory-related proteins. Our results
support the hypothesis that already in mid-life, genetic, and
environmental risk factors act together on the mechanisms behind
cognitive impairment."
